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SAIC has greatly benefited from compact organizational space in building technological capabilities, as it encourages the mobilization and integration of internal resources and promotes group-wide synergy for an effective internalization of acquired assets.
The data of CLSM and FCM proved the effective internalization of the laden micelles by RenCa cells.
Compared to PDM/DOX and PLM/DOX, SCM/DOX exhibited smaller diameter, slower DOX release in vitro, and more effective internalization by RenCa cells.
The ICP-OES measurements in stem cells (RADMSC) and in cancer cells (HeLa) confirmed that silica-coated CdSe QDs have excellent effective internalization efficiency and the peak concentration was observed after 4 hours.
Through this study, it was revealed that the 50 nm sized drug-silica nanoconjugate particles had highest cancer tissue retention over time leading to deeper tissue penetration and effective internalization within the cancer cells along with slower clearance [65].
The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen presenting cells.
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Small cisplatin-encapsulated liposomes (<200 nm) are effective in killing cells due to their efficient internalization by cell endocytosis.
To validate that TRITC-NPs were indeed internalized by BMDCs, fluorescent micrographs of fixed BMDCs following 30 min incubation with either TRITC-NPs or b-NPs demonstrated efficient internalization of fluorescent NPs by BMDCs, an essential process required for effective antigen processing and presentation following uptake of antigen-encapsulated NPs.
The CLSM demonstrated the more effective cellular internalization of HFNDs than NDs.
The CLSM demonstrates the more effective cellular internalization of NDs than that of nanospheres with a much smaller size.
The in vitro GSH-activatable fluorescence imaging and PDT studies of free Ce6 and GO SS Ce6 towards human lung cancer A549 cells (dark incubation for 24 h followed by diode laser irradiation at 670 nm, 20 J/cm2) showed effective cellular internalization and preferential accumulation of Ce6 in the cancer cells, especially in the lysosomes (Fig. 42).
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