Based on previous studies, we hypothesize that novel interactions might not be as effective at initial stages of invasion stages as those interactions that have coevolved together (Rodríguez-Echeverría et al. 2012).
In Figure 1, it is also noted that the financial incentive might only be effective at the initial stage of each subsidy program (Chang et al. 2013b).
However, enzymes are usually only effective at the initial stage after addition and become inactive soon afterwards.
We speculate that the stimulation of APOBEC, the enzyme group that exchanges G for A in viral nucleic acids and is usually inhibited by the HIV protein Vif, has been amplified and made effective from the initial stage of the infection.
(74) Regulation (EC) No 2887/2000 of the European Parliament and of the Council of 18 December 2000 on unbundled access to the local loop(15) has proved to be effective in the initial stage of market opening.
(77) Regulation (EC) No 2887/2000 of the European Parliament and of the Council of 18 December 2000 on unbundled access to the local loop(15) has proved to be effective in the initial stage of market opening.
The Youth Actuarial Care Needs Assessment Tool for Non-Offenders can be administered by Dutch police officers and since it is solely based on police records and comprises only six items, it can easily be implemented in the Dutch police system, making the instrument efficient and cost-effective in the initial stage of risk assessment.
According to Lewis, who is tracking incidences of police brutality and discrimination against deaf people across the nation, effective communication during this initial stage is critical to preventing wrongful arrest and convictions.
In fact, it was paradoxically reported that PI3K inhibition is effective only in the initial stage of infection [13], [14], indicating a bivalent role for PI3K in both early and late stages of infection.
This provides a clue towards the fact that the S protein and N protein (having targets corresponding to these miRNAs) of SARS-CoV takes advantage of this and escapes miRNA-mediated repression which is a rescue to the virus for effective transmission at the initial stage of viral infection.
In addition, we demonstrated our FBDD strategy integrating highly sensitive biochemical assay, X-ray crystallography, and high-throughput synthesis and in silico library design aimed at fragment morphing at the initial stage was effective to elucidate a pocket profile and a promising lead compound.
