Three variables (extraction time, magnetic sorbent amount, and pH value) were selected as the main factors affecting the sorption step, while four variables (type, volume and concentration of the eluent; and elution time) were selected as effective factors of elution step in the optimization study.
Computational virtual screening has played a critical role in the initial lead discovery associated with many of these compounds, and the computational structure-based approach is particularly effective in lead optimization.
Surrogate-assisted evolutionary optimization has proved to be effective in reducing optimization time, as surrogates, or meta-models can approximate expensive fitness functions in the optimization run.
The proposed algorithm is shown to be robust and more effective, in the tested examples, than conventional optimization algorithms, leading to optimum designs of ISP cross-sections for a pre-defined buckling load-carrying capacity, combined with elasto-plastic nonlinear behaviors.
It is partially based on the principles of the scatter search methodology, but making use of innovative strategies to be more effective in the context of complex-process optimization using a small number of tuning parameters.
However, TLBO is not capable or effective in DSP optimization problems with discrete solution spaces and complex disassembly precedence constraints.
Thus, CL therapy was both safe and effective in allowing optimization of glycemic control under both sedentary and exercise conditions.
The optimization requirement in turn, establishes the need to develop fast and effective approaches to the optimization procedure, providing the best predictive power of the constructed model.
Finally, we show how standard procedures, such as robust metrics and multi-scale optimization schemes, are also effective in the microscopy imaging domain to improve performance.
