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Autologous cells engineered to produce antiinflammatory cytokines were also effective in the mouse CIA model.
Drugs that are effective in the mouse model, individually or in combination, would then be considered as a therapeutic option for the patient.
JNJ-18038683 was also effective in the mouse TST [ 16].
Last but not least, cell type may explain our failure, even though BMMC were effective in the mouse model.
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We report a detailed characterization of its biochemical composition (protein content and profiling by size-exclusion chromatography and electrophoresis) as well as the specific and para-specific neutralization potencies (as median effective dose in the mouse lethality test).
Overall these data show that the p130Cas/Cox-2 p130Cas/Cox-2tive both in the mouse axisis theffectiveetting.
Although we cannot rule out that miR target sites lead to a more effective silencing in the mouse retina than in vitro, our in vitro experiments suggest that features of the mRNA external to the miR target sites rather than miRNA levels might affect the efficiency of the silencing.
What prevents KRAS from being 100%% effective in this mouse model? 4.
We found that clearance of SWCNTs was ∼10-fold less effective in the gp91phox mice vs w/t animals.
We show that riluzole, which normally is not effective when given at onset of symptoms, is now effective in the ALS mice when administered in combination with the P-gp/BCRP inhibitor elacridar.
Exon skipping is effective in the mdx mice where, through the use of AAV vectors expressing U1-snRNA antisense molecules, efficient rescue of DYS was obtained together with recovery of correct tissue morphology and integrity (this work and Denti et al, 2006a, 2006b, 2008).
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