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These experimental results suggest that our new method has the potential for efficiently extracting reliable miRNA/target-gene pairs and may be effective in the elucidation of the primordial regulatory relationships between miRNAs and their target genes during the early stage of bilaterian evolution.
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Within the framework of a larger study on fossil seed cones, microCT coupled with scientific visualization, 3D image segmention, and computer animation proved to be extremely effective in the nondestructive elucidation of internal structures and features, such as number of seeds per cone scale, and phyllotaxy of the seeds and cone scales.
Through a case study, the use of LC MSn technique in conjunction with a mechanism-based stress study is shown to be a very effective way in the rapid elucidation of unknown drug impurities.
The identification of rapamycin from Streptomyces hygroscopicus as an antifungal agent, through being an immune inhibitor to being an effective anticancer drug, demonstrates a research continuum driven by clinical observations that were critical in the elucidation of the mTOR pathway.
The other polarographic methods were also used in the elucidation of the electrode process.
A trained placental pathologist can examine a placenta and assist in the elucidation of the causes of poor pregnancy outcome.
Recent progress in the elucidation of the molecular mechanisms of viral pathogenesis has opened up new opportunities to manipulate virus-host interactions, generating effective anti-tumor strategies.
It is extremely helpful in the elucidation of ligand promiscuity.
Examples presented here illustrate the role of autoantibodies as tools in the elucidation of the autoimmune components of cellular ribonucleoproteins.
In this special issue, we present recent advances in the elucidation of gene regulatory networks (GRNs).
Identification of effective paraptotic inducers and the elucidation of critical signals involved in this alternative cell death mode may facilitate the design of novel therapeutics against malignant cancer cells with defects in their apoptotic machineries.
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