This work represents the first demonstration that the MUC1-C cytoplasmic domain is a direct drug target and that inhibition of MUC1-C oligomerization is effective in inducing the complete regression of established human breast tumour xenografts in preclinical models.
30 Perhaps a new model of obesity care should join PCPs, nutritionists, and other relevant health professional together an approach which proved effective in the recently completed POWER trial, 31 which examined the effects of behavioural weight-loss interventions among obese patients.
Finally we should mention that the elimination of satellites by random drift may not be sufficiently effective to result in the complete disappearance of large satellite families, which may have hundreds of members: an additional mechanism might be required.
In one study cyclobenzaprine has demonstrated to be effective in the improvement or complete relief of headache in half of 20 TTH patients, whereas only partial relief was obtained in one-third of patients treated with placebo [237].
The monovalent reagent, in a wide range of concentrations, is as effective as the complete antibody in modulating sIg from rabbit B cells.
For instance, many anticancer therapies are evaluated based on their ability to shrink tumors, but if the therapies are not effective in complete elimination of the CSCs, the tumor will soon grow back [ 8, 9].
59 It was also effective in producing complete regression of the Hh pathway dependent medulloblastoma allograft model generated from Ptch+/− mice.
Using a stepwise design, pharmacokinetic/pharmacodynamic modeling was used in which a target trough siltuximab serum concentration of 21 μg ml 1 was predicted to be effective in maintaining complete CRP suppression throughout the dosing interval (Puchalski et al, 2010).
Although targeting proteinuria directly is the most commonly used and effective treatment in the clinic, complete annihilation of proteinuria is very difficult and attempts to do so resulted in increased mortality (Nangaku, 2004; Khan et al., 2013; Hou et al., 2007; Chen et al., 2014).
