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Statins, the drugs that are broadly prescribed to block the body's cholesterol synthesis, were first found effective in studies of people who inherited a rare gene that led to severe and early heart disease.
Testing this hypothesis is consequently more straightforward and can be accomplished using methods proven effective in studies of both mammals and dinosaurs.
Co-stimulation blockade is another strategy to suppress the consequences of autoantigen presentation, and this has been shown to be effective in studies of belatacept to suppress alloimmunity after kidney transplantation [ 55].
Rat models have proven effective in studies of social stress (Grissom 2007; Sirivelu et al. 2006), air pollution (Batalha 2002), and asthma (Kodavanti 1997) and as a standard for inhalation bioassays and fuel emissions testing (Hesterberg et al. 2005).
It has proved to be highly effective in studies of vulnerable, stigmatised, deviant or closed social groups, such as drug takers, homeless people or those affected by HIV/AIDS, as it enables in-depth knowledge of group beliefs and behaviours to be built up and gaps in knowledge to be identified and filled [ 35, 36].
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We determined whether levels of oxidatively damaged DNA and lipid peroxidation products in cells or bodily fluids from humans are useful biomarkers of biologically effective dose in studies of the health effects of exposure to particulate matter (PM) from combustion processes.
As a result, the interpretation of BPDE-adducts as indicators of effective dose in studies of DNA methylation is not clear.
This cell line has been widely used as a model for studying new potential drugs on various aspects of macrophage functions, being an effective model in studies of anti-inflammatory activity [ 39].
The use of population genetic data to investigate effects of chronic contaminant exposure has proven effective in studies representing a diversity of organisms and ecological settings.
Neither of these methods is effective in field studies of wild avian populations because the viral inclusion bodies typically occur in the dermis and are thus inaccessible to non-invasive sampling methods.
Inhibition of FGFR3 has been effective in preclinical studies of MM.
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