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The uptake of FAs from the culture medium was not effective in reverting such effect; supplementing the medium of the induced culture with linoleate was equally ineffective, like before for TS-treated cells (data not shown).
These findings, together with the observation that at variance with Ro 32-0432, rottlerin was only partially effective in reverting the effect of PMA (Table 2), may suggest that different isoforms of the enzyme play distinct roles in modulating the responses to TTN.
"Drug holidays", the temporary cessation of drug treatment, may prove effective in reverting drug resistance.
As demonstrated in Fig 4C, nutrient refill was effective in reverting the up-regulation of PGC-1α, UCP1 and Cidea.
Thus, treatment with the epigenetic inhibitors is effective in reverting some of the tumor-specific transcriptome to a normal pattern.
It is the only seizure suppression that is effective in reverting para bss1 phenotypes, although it is effective only with heterozygotes, and not homozygotes or hemizygotes.
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Compound 9 (1 mg/kg, ip) was fully efficacious in reverting scopolamine-induced amnesia in mice.
Although the pioglitazone dose in ACT NOW was 45 mg/day, lower doses (15 30 mg/day) improve insulin sensitivity and insulin secretion (160a) in type 2 diabetes and were effective in decreasing IGT conversion to type 2 diabetes and in reverting IGT to NGT in ACT NOW (21).
This suggests lower doses of MSKE can be more effective at reverting EMT than higher doses, possibly by inhibiting superoxide.
Treatment of ARCaP-Snail med and-Snail high cells with 5 μg/ml MSKE was more effective at reverting EMT than 20 μg/ml MSKE, as shown by greater re-expression of E-cadherin and decrease in vimentin protein in Western blot analyses when compared to untreated or control EtOH treated cells.
SAIDs were most effective to revert the molecular changes from the 'diseased' to the 'healthy' pattern.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com