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A hallmark of modern biology is tremendous amounts of complex omics data, which require large-scale data management, comprehensive computational analyses, fast retrieval and efficient integration for better understanding of the data and more effective hypothesis generation.
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These properties make mechanistic network models ideally suited to approach the problems of identifying drug resistance mechanism and designing effective hypothesis-based drug combinations.
Such studies have been effective hypothesis-generating tools for separating the relative genetic and environmental contributions to disease, including asthma[ 28].
Alternatively, molecular genetics can be used in combination with metabolomics as an effective hypothesis-generating tool to discover new metabolic functions: the disruption of a pathway of interest might lead to the upregulation of alternative pathways to compensate for the lost function(s).
We view ChIP-PED as an exploratory tool for fast and cost-effective hypothesis generation and screening.
The method is based on a recently developed centering procedure where the notion of a perturbator is introduced in terms of boundary interface integrals that makes it possible to reconsider basic concepts of micromechanics such as effective field hypothesis, quasi-crystalline approximation, and the hypothesis of ellipsoidal symmetry.
The method exploits as a background the new general integral equation proposed by the author before and makes it possible to abandon the use of the central concept of classical micromechanics such as effective field hypothesis as well as their satellite hypothesis of "ellipsoidal symmetry".
The operator representation of this solution is incorporated into the new general integral equation of micromechanics without exploiting of basic hypotheses of classical micromechanics such as both the effective field hypothesis and "ellipsoidal symmetry" assumption.
Quantitative estimations of results obtained by the abandonment of the effective field hypothesis are presented.
This illustrates an interesting contrast between our three versions of the effective continuum hypothesis, namely, that they can come apart.
Medium-term momentum and long-term reversal will generate excess returns, which are contrary to the effective market hypothesis.
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