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Incorporation of effective backbone sampling into protein simulation and design is an important step in increasing the accuracy of computational protein modeling.
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In view of the prototypical nature of the proposed model, our general conclusions pertain to a variety of other biological systems where elastic interactions are mediated by effective backbones.
Our ns2-based simulation results show that the design criteria chosen for CC are effective in producing backbones that can be reconfigured quickly and with remarkably lower overhead.
Fellmann, C. et al. An optimized microRNA backbone for effective single-copy RNAi.
Copolymerization strategies involving the insertion of flexible PEG side chains along the network backbone proved effective in enhancing network free volume and increasing permeability.
The aging but still effective Tornado forms the backbone of the British strike force.
Frontline health workers are really the backbone of effective health systems in developing countries.
These statistics represent the backbone for effective livestock-sector policies and investments.
They are extremely effective and form the backbone of many cancer treatment regimens used today.
The potential for capecitabine as the backbone of effective combination regimens has been established in numerous studies in breast, colorectal and gastrointestinal malignancies.
Our data indicate that 3'-modified CpG ODNs consisting of a PD backbone are effective at resisting nucleolytic degradation, and that the number of CpG core motifs strongly influence their potential as hTLR9 agonists.
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