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The single knock outs were regulators for respiration effecting a large number of genes and also the treatment was rather unspecific (growth in oxygen rich and deprived conditions).
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This will ultimately effect a large number of leading U.S. companies who have tirelessly promoted over the last few years the global nature of their businesses.
Felix and Fursey both effected a large number of conversions and established many churches in Sigeberht's kingdom.
The further investigations conducted in literature indicated that such undesirable failures can be effected by a large number of geometrical and material parameters.
With concern about the consumption of fossil fuels and the resulting greenhouse effect, a large number of sustainable energy sources are connected to the utility grid in the form of DGs.
To that effect, a large number of patients would be needed, only possible in multi-centric studies.
With the current high prevalence and unavoidability of night shift work and its potential health effects, a large number of people worldwide may be at increased risk of several chronic diseases.
Meta-regression will quantify how much of the between-trial heterogeneity is explained by the various drug doses used, and is most useful when there is a significant treatment effect, a large number of studies, sufficient between-study variation in the postulated confounding variable, and sufficient heterogeneity among the treatment effects [ 25].
The disease model we used for the simulation assumes that the genetic factors of the disease can be decomposed into a small number of large effects and a large number of small effects that can be approximated by a normal distribution (see Methods).
This represents independently useful information, as it indicates whether the estimated heritability is likely due to a small number of large genetic effects, or a large number of smaller effects.
Although the study design precludes direct cause-and-effect conclusions, we infer that effects from a large number and broad range of factors seem to influence which procedures GDs provide in their practices.
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