These results support the idea that the ΔarcA mutation indirectly effects the expression of the ato system, possibly mediated by an altered polyamine metabolism.
Our global gene expression profiling of MG-treated macrophages revealed that MG effects the expression of numerous genes, many related to apoptosis, activation, and immunity.
We wanted to determine if a neuroprotectant, such as IGF-I, could effect the expression of miRNAs that are known to be altered under ischemic conditions.
Since early follicle development is thought to be activin-dependent [27]; [29], [29], we questioned whether activins could effect the expression of inhibin subunits and PCSKs during follicle development.
Thyroid hormone also effects the expression of phospholamban.
As shown in Figure 6a,c, knockdown of Brk did not effect the expression of STAT5b and knockdown of STAT5b did not effect the expression of Brk.
Bcl-2 expression was significantly reduced, whereas metformin did not effect the expression of Bim and Puma (Fig. 5C).
Further, in cases where multiple phenazines are produced, distinct phenazines may effect the expression of different or overlapping gene sets.
Despite the severe and pervasive cytopathic effects, the expression programs in the poxvirus-infected cells were surprisingly similar to those in the mock-infected cells.
We are now looking into what effect the expression of α v β6 has in these systems.
