Second, the original effect size and the replication effect size will be combined into a single effect size using a meta-analytic approach and will be presented as a forest plot.
If there is some evidence of clinical differences between interventions, the incremental costs and effects between the interventions will be combined to estimate the incremental cost-effectiveness of one intervention over another, i.e. a cost-effectiveness analysis (CEA).
The effect sizes at this stage will be combined using the DerSimonian and Laird random effect models to allow for appropriate inter-MA heterogeneity assessment.
Costs and effects (in terms of QALYs) will be combined in the incremental cost-effectiveness ratio (ICER).
In such trials, both the efficacy of adjusted treatment in normalizing response and the effect of inaccuracies of prediction will be combined.
The outcome from the participating clinics will be combined if no gross center effect is found.
This response will be combined with effect of immune cells (because they secrete cytokines) during in vivo infection.
The effects of the raw materials onto the product's final quality attributes (FQA) will be combined with the effect from the process operation, and from any differences of scale.
Exclusive behind-the-scenes looks at the film version, with its fantastical effects, striking scenery and scary twists, will be combined with products specifically created to evoke the film's themes of beauty and power.
18 Prevalence data from individual studies will be combined by random-effects meta-analysis according to the Mantel-Haenszel method.
