Most of the confirmed associations within these loci are with common variants, of modest effect, which well-designed GWAS is adequately powered to detect.
A possible reason for the lack of dormancy behaviour in the laboratory fish may be due to a disturbance effect, which is well documented to interrupt hibernation and delay the entry into dormancy of many hibernating animals [23].
This is central to your paper because of the very real possibility that the observed QTL hotspots (which mostly differ from another RIL population) are due to rare alleles of large effect, which may well be deleterious.
This effect, which is well known for blocking NKCC2, is the consequence of a defect in the urinary concentrating process due to diminished Na+, K+ and Cl− cotransport in the TAL.
Thus, manifestation of the gastrin-induced anti-apoptotic effect which is well documented in literature [ 24- 27], requires sustained gastrin treatment and is not induced when cells are exposed to gastrin for only 1 hour.
In an answer that is worth quoting at length, Snowden cited two: The first is the chilling effect, which is well-understood.
The first is the chilling effect, which is well-understood.
Among the 23 studies that did report such an impact, 21 studies (91.3%) reported a positive effect which included well-designed and conducted large RCTs [ 33, 36, 37, 54, 56, 57].
However, this approach is not able to explain the observed sheet thickness (t) effect, which is also well known in seam welded joints, whereby fatigue lives are shorter in sheets of greater thickness when the structural stress is kept constant.
However, there was substantial heterogeneity in the size of the effect which was not well explained by a series of subgroup analyses (Analysis 3.2 to Analysis 3.9).
A phenomenological material model accounting for both temperature and strain-rate effects has been developed, which well describes the compressive and failure behaviors at various strain rates and environmental temperatures.
