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In addition, this effect was validated in the hip joint simulator FIME II.
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Findings from in vitro and in vivo studies support this notion of proposed synergy, although this hypothesis can only be taken forward when the observed treatment effect is validated in various settings and in a larger number of patients.
The QTL effects were validated in backcross populations.
The effects were validated in an embryonic kidney cell line (HEK293T) and in HLRCC-patient derived cells (UOK262) via both genetic and pharmacological inhibition.
Immune functions relevant to aging and inflammation, and to cancer and infections, and innate lymphoid cell effects were validated in vitro and in vivo.
Furthermore, this effect was validated among white and black subjects recruited in the ARIC and CHS cohorts.
The optimal dose of Remifentanil was determined in a pilot study where the desired analgesic effect was validated.
Finally, the prognostic effect of Sox11 was validated in an independent set of 72 glioblastoma patients.
Analysis of the data revealed upregulation of 292 common genes across the cell lines after Decitabine treatment, and the treatment effect on demethylation was validated in selected strongly upregulated genes, such as CDKN1A and TGFBI.
A further concern is that the NDI has not been validated for treatment effects, and the SODA was validated in a non-representative patient population comprising 96% men [ 24].
The effect is validated by stochastic simulations in Figure 2 (d).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com