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This effect was dramatically reduced when the macrophages were treated with caspase-3-deficient EVs, either in the absence or in the presence of hyperoxia.
Both EVG016 and EVG017g displayed lowered infectivity as expressed by greater LD50 values compared to the wild-type parent, although due to the slopes of the dose-response curves the effect was dramatically reduced at LD95 values.
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Moreover, although mitochondrial oxidation under the Warburg effect is dramatically reduced, many cancer cells still have a central requirement on mitochondrial metabolism, strongly suggesting that OXPHOS inhibitors might represent an important target for drug-resistant cancers [121].
Interestingly, the number of tubules with vacuoles is positively correlated with age, but the significance of the age effect is dramatically reduced for the more severe phenotype (Table S5).
These effects were dramatically reduced and became more focal in JWH133-treated rats, especially for high dose.
In the most conservative estimates the effect size was dramatically reduced and the estimate was no longer statistically significant (Analysis 6.1).
Tuber glucose concentration, which was directly selected against due to its effect on chip color, was dramatically reduced in the late 1960s with the advent of the Chip Processing class, and has seen modest reductions since that time.
Blocking TGFβ-ALK5 signalling by therapeutic dosing with the potent and selective ALK5 antagonist SB525334 was highly effective in blocking the progression of fibrosis in the single-hit bleomycin-alone injured mouse model, but the anti-fibrotic effect of this agent was dramatically reduced in the presence of concomitant viral infection.
As a consequence, caries prevalence was dramatically reduced.
However, despite having similar levels of infection at the earliest time point, the survival of the H37Δ Rv0561c bacilli in the macrophages was dramatically reduced, an effect that was obviated by complementation.
Leakage was dramatically reduced.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com