And more than other similarly amorphous literary effects — tone, mood, atmosphere — voice seems intimately connected to the human speaker behind the text.
However, the recent withdrawal of diarylheterocyclic selective COX-2 inhibitors due to adverse cardiovascular side effects toned down the initial enthusiasm surrounding the launch of selective anti-COX-2 drugs [4] [6].
Unlike activations in the medial grid, activations in the lateral grid showed no main effect of Tone Frequency (F 2,16) = 0.50) nor were there significant interactions between Tone Frequency and A-P grid location (F 30,240) = 0.95).
There was a main effect of Tone Frequency on All-ASA activation magnitudes (F 2,16) = 4.61, p<0.04): 900 Hz tones produced greater mean percent signal change (SDAs = 0.34%) than either 3600 Hz (0.28%) or 225 Hz (0.30%) tones.
There was also a main effect of tone frequency on auditory activations in medial auditory cortex: activation magnitudes were larger to 900 Hz tone patterns than to tone patterns centered at 225 or 3600 Hz.
In writing, our sensitivity to small sounds is such that a minute alteration in decorum can have a very big effect on tone.
Testosterone increased action binding but there was no significant effect on tone binding.
To reduce the effect of tone decoder output glitches, the circuit adds an RC filter.
Other F0 transitions - termed 'pitch interrupters' by Isačenko - will occur at phrase boundaries or in unstressed syllables where they do not have the same prominence-lending effect as tone switches (see [14]).
As the inner layer of blood vessels, endothelial cells have unique functions in vascular biology, including barrier effect, vascular tone control, blood clotting regulation and inflammatory response (Bochenek et al., 2016; Hansen et al., 2017; Sturtzel, 2017).
