These effects are consistent with the time frame of acetylation of H4 and H3 induced by the two drugs at IL3 promoter.
The auxin effect on vacuoles was in the time frame of fast transcriptional responses and, subsequently, we tested whether the TRANSPORT INHIBITOR RESISTANT1 (TIR1)/AUXIN F-BOX PROTEINS (AFB) auxin receptors (Leyser, 2006; Mockaitis and Estelle, 2008) are required for the auxin effect on vacuoles.
Seasonal effects only become important if the time frame of recruitment is relatively short.
The existing human data thus appear to mirror the time frame of effects seen in animals.
Consistent with these findings, targeted knockdown of AhR2 in zebrafish embryos with antisense morpholino oligonucleotides (MOs) prevented all of the toxic effects of TCDD that occurred within the time frame of morpholino efficacy (Prasch et al. 2003; Teraoka et al. 2003).
Given the time frame of these effects, we suggest that the primary mechanism of CLR01 action is via its direct effect on the virus, and that the anti-amyloid effects, although potent, play a secondary role.
No cytopathic effects of adenovirus infection were observed within the time frame of the experiment.
A real-time measurement able to track hemodynamic changes in the time frame of PLR effects, i. e., 30-90 s, must be used.
Generally, the VFA yield increased with time and no effect of the reactor type used was found within the time frame of the experiment.
In support of such a scenario, abrogation of c-Abl activity, within the time frame of the c-Abl effect on repair, significantly reduces cellular radiosensitivity and increases post-irradiation clonogenic capacity, results which are also in accordance with a finding that STI-571 protects mouse oocytes from chemotherapy-induced death.
