However, the association with rs558907 produced a substantial and significant effect on the linkage signal when adjusted for the effect of rs2276064.
It is noteworthy that in the initial analyses of the effect of TREH variants on trehalase activity, some of the SNPs had a negligible effect on the linkage signal, despite strong evidence for association (e.g., rs558907).
First, it has been proposed that these physiological changes in obese persons might occur as a side effect of the linkage between the immune system and satiety.
There is the potential for errors in record linkage, but this is unlikely to have a marked effect as the linkage process is estimated to be 98% accurate (Harley and Jones, 1999).
Kendrick's paper expands on the principles outlined by Newcombe [ 29, 30] which describes the factors which could have an effect on the linkage quality, including the likelihood that a record in one file is represented in the matching file.
While ANP may not have a direct negative chronotropic effect, the receptor linkage to the guanylyl cyclase in rabbit atrium [39], rabbit [40] and rat ventricle [41], [42], as well as rabbit Purkinje fibers [43], [44] has been proven.
Even if the key genetic factors have been identified, there may always exist genetic variants with such minute effects on the linkage signal that they are essentially undetectable.
Thus, in at least three instances (A, R and Np) it is not necessary to postulate a closely linked set of genes that form a co-adapted complex in order to explain this clustering of effects on the linkage map.
To reduce the effect caused by the linkage disequilibrium (LD) between closeby SNPs, one tries to partition SNPs that are in strong LD into distinct groups.
