Among the SNPs that had a positive effect in the discovery population, 66% also had a positive effect in the validation population and among those that had a negative effect in the discovery population, 56% also had a negative effect in the validation population.
The effect of AMI is stronger in the replication phase, but the vast majority of the genes showing highly significant differential expression in either direction in the replication phase (red or blue spots highlighted in Figure 1D) showed the same direction of effect in the discovery phase, indicating replication of the AMI effect.
Vice walked through the evidence to that effect, including early analysis from a cybersecurity firm to that effect and the discovery of Russian language metadata in the document dump that was later removed.
This replication includes a P value for the summary effect (excluding the discovery data set) of P < 10−7, even in random-effect models that account for between-study heterogeneity or have a false-positive report probability rate less than 10% or a Bayes factor less than 10−5.
It is hard to realise now the effect that the discovery of the Lascaux paintings had in the post-war period: those images haunted the imagination of a generation.
For centuries philosophers have pondered the effect that the discovery of extraterrestrial life might have on human religions – could Christianity sustain itself in the light of evidence that we are not alone?
Lennon cites the effect that the discovery had on him: "'Suddenly,' he said, 'I realized you could write about your own life.'" When Mailer wrote "The Naked and the Dead," he wrote about his experience of battle in the Second World War (albeit not in a first-person voice).
In a 1992 interview with The New York Times, referring to the effect that the discovery of oil in Venezuela more than 80 years ago had had on the nation, Mr. Uslar Pietri said: "Venezuela is not a country -- it's a country glued to an industry".
Exploration of the mechanisms underlying the post-glucose effect and the discovery of elements to overcome this phenotype will be the focus of future research.
"When we look at the impact that is having on the ocean, the levels seem to be within past trends and so we don't believe it's having an effect". But the discovery is another setback for Tepco's plan to pump groundwater from the plant into the sea, correspondents say.
