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Interestingly, adding secretions (35 µg/ml) to fully differentiated macrophages did not lead to a reduced production of IL-12p40 or TNF-α (data not shown), indicating that secretions effect the differentiation of the cells.
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It is also hypothesized that Dex has no direct effect on the differentiation of hPDCs, instead its effect is to augment differentiation in combination with other factors.
We did not find that MBP had any effect on the differentiation of NPCs.
These data suggest that in addition to the number of B1 B progenitors, Siglecg exerts a general repressive effect on the differentiation of the B cell compartment.
We have prepared myelin from adult rat spinal cord and assessed its effect on the differentiation of NPCs (see Fig 1B).
Moreover, the silencing of MICL expression has no effect on the differentiation of PLB-985 cells.
Age is known to have a strong effect on the differentiation of the adult immune system.
Former research could show that the use of collagenase type I has a negative effect on the differentiation of tenocytes.
IL-6 has a cell-proliferative effect, triggering the differentiation of megakaryocytes to platelets in the bone marrow [ 70, 71].
To further clarify the possible mechanism involved in the positive effect on the differentiation of cementoblasts, we analyzed the expression of sclerostin after incubation of 7 days.
Similarly, IL-6 has a cell-proliferative effect, triggering the differentiation of megakaryocytes to platelets in the bone marrow (Imai et al, 1991; Ruscetti, 1994).
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