In these models (commonly referred to as "state-dependent networks" or "liquid state machines") the distributed synaptic dynamics encodes input history in an analogous way as we discussed in this paper for a single neuron: each input to the network will have an effect that depends upon the previous network history.
Myelosuppression is another major side effect that occurs upon treatment with 5-aza/5-azadC.
"Imagine what might happen when India and China get the pedal to the metal in terms of data center growth and the effect that will have upon global energy consumption in the sector," said George Rockett, a co-founder of DatacenterDynamics.
That is one of many anecdotes shared in David Kirkpatrick's The Facebook Effect that sheds light upon Mark Zuckerberg, the enigmatic and very young founder of Facebook.
PQQ deficiency resulted in a reduction in the relative liver weight when compared with body weight, an effect that was reversed upon PQQ repletion.
In T47D cells, PRL down-regulated LKB1 transcriptional activity, an effect that was reversed upon culture in phenol red-free media.
The significant interaction between treatment arm and amount of weight loss in the initial weight-loss program suggests a treatment effect that varied depending upon initial weight loss.
Moreover, FLRG silencing through small interfering RNA (siRNA) induced significant tumor growth inhibition, an effect that was reversed upon the addition of exogenous FLRG [ 17], demonstrating that FLRG antagonizes activin effects in neoplastic cells.
We and others have shown that inhibitors of Hsp90 enhance the degradation of mutated or hyperphosphorylated tau in vitro and in vivo, an effect that is dependent upon the presence of CHIP (9, 14, 27).
Given this finding, it was not surprising that PTEN-deficient cells are 20-fold more sensitive to PARP inhibitors, an effect that was reversed upon expression of PTEN or RAD51.
The activity of a LKB1 promoter-luciferase reporter construct was significantly enhanced by PRL in MDA-MB-231 cells, an effect that was lost upon truncation of the distal promoter region containing a putative GAS/STAT binding site.
