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9 We aimed to establish that treatment effect, safety, quality of life, and cost effectiveness of home phototherapy do not differ substantially from that of conventional ultraviolet B phototherapy in an outpatient clinic.
The main benefits of the approach and the subsequent development of an SPI are (1) the identification of pertinent variables that effect safety at both intersection types, (2) the identification of similarities and differences at both types of intersections through model comparison, and (3) the quantification of safety in the form of an index such that a ranking system can be developed.
Although these oncolytic viral treatments exhibited a strong therapeutic effect, safety might be a problem because the virus with an intact genome still exists in noncancerous cells [ 29].
This single center, randomised controlled, open label trial assesses the therapeutic effect, safety and tolerability of the mTOR inhibitor sirolimus (Rapamune®) in patients with autosomal dominant polycystic kidney disease and preserved renal function.
While harm outcomes may be the most sensitive and valid endpoints to evaluate the implementation of systems that effect safety, it is unethical in prospective studies to let the consequences of professional or system errors reach the patient.
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Officials in the latter group are focused so narrowly on "safety" that they ignore the fact that because all drugs have side-effects, safety cannot be evaluated in a vacuum.
Two authors independently abstracted relevant information (e.g., study sample, intervention characteristics, treatment effects, safety data).
Does not introduce potentially dangerous side-effects (Safety).
Results from the study regarding the medical effects, safety and costs of the two strategies will be available in late 2005.
Participant-reported adverse effects (safety) were pre-defined as any unfavorable change from 'normal' condition that limited everyday living.
The data from this population are consistent with previous reports of the clinical effects, safety, and tolerability of peramivir [ 8, 17– 19, 28].
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