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Exact(14)
If the embolus is small, it may not have any effect on the systemic circulation.
Inhibition of Mac-1 upregulation by NPC-15669 attenuates the increased regional platelet aggregability resulting from myocardial ischemia-reperfusion, with a less marked effect on the systemic response.
This suggests that many microglia may have undergone a change in polarization to the M2 phenotype, thereby reducing secondary brain damage, as brought about by the immunomodulatory effect on the systemic inflammatory response.
Genetic variation in CYP3A4/5 and SCL01B3 had no effect on the systemic exposure.
This new concept may shed further light upon the mechanisms involved in the GLP-1-inducing effect on the systemic metabolic disorder.
Because it is rapidly inactivated by hemoglobin, this mode of administration produces little, if any, direct effect on the systemic vasculature.
Similar(46)
This may explain, in part, the effect of the systemic inflammatory response on the poor survival of patients with advanced renal cancer receiving alpha-interferon immunotherapy.
It is concluded that the relative effects on the systemic and pulmonary circulations differ for the four drugs; rational choice of a vasopressor will depend upon the hemodynamic situation and the desired effect.
And the compounds exhibited difference inhibitory effects on the systemic synthesis of TMV-CP.
It is not known if high frequency NMES has comparable effects on the systemic microcirculation of skeletal muscle.
As the potential of this or other similar compounds for treatment of portal hypertension is evaluated, effects on the systemic vasculature will also need to be considered.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com