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On the other hand, changing the concentration of the divisor had no significant effect on the specificity of MET determination, therefore, normalized spectrum each of MEH and DF was used as a divisor.
The TaqIA polymorphism, causing an amino acid change in ANKK1 (Glu713Lyseemseems to have a significant effect on the specificity of substrate binding.
The presence of the ACP had little effect on the specificity (kcat/ KM) of the cis-AT domain for carboxyacyl-CoA substrates but had a marked influence on the corresponding specificity parameters for the trans-ATs, suggesting that these enzymes do not act strictly by a canonical ping-pong mechanism.
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Additionally, through the effects of the specificity acupoints on the CORT level in peripheral blood, and on the expressions of CRH and GR protein in PVN in unpredictable chronic mild stress (UCMS) model rats, the effects of the acupoints were verified so as to further explore the acupoint specificity on the regulation of PHAA function.
All in all, these data suggest that WFDC1 is a multifunctional protein and that its end point effect depends on the specificity of the cell or its context.
For example, the enzymes to degrade extracellular matrix or exopolysaccharide (EPS) were shown not only to inhibit biofilm formation, but also to remove pre-existing biofilms effectively, although the effects depend on the specificity of EPS matrix composition of biofilms [10] [13].
The lid domain of lipase is an interesting portion which has a large effect on the substrate specificity of the enzyme.
The I214V mutant displays a visible shift of surface charge distribution that may have a potential effect on the binding specificity and affinity with other chaperones.
Although the molecular basis for these differences will require additional investigation, our results indicate that both LevT and LevQ are required for signal transduction by the complex, and that LevQ in particular has a profound effect on the substrate specificity of the system.
The substitution of T218 did not have a strong effect on the coenzyme specificity.
Inclusion of nonexcised lesions [ 12, 34] can have a positive effect on the observed specificity, since these lesions do not resemble malignant lesions.
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