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Autophagy induction clearly represents an appealing approach for HD treatment; however, the therapeutic window remains to be determined as mutant HTT has a negative effect on the sequestration of the autophagic cargo.
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In response to this comment of the referee, we have modified the text by emphasizing how the partial stalling of clathrin coated pit maturation at mid-stage (U-shaped pits) may only be an indirect effect of the sequestration of endocytic factors on uncoated vesicles.
The bioenergy-oriented land use change always refers to conversion from arable to perennial grasses or growing bioenergy crops on marginal croplands, which has positive effects on the SOC sequestration.
In respect of afforestation of former arable sites, the most evident effect on C sequestration was the net sink of atmospheric CO2 with C accumulation mainly in the growing trees and the forest floor [7 11].
In respect of afforestation of former arable sites, the most evident effect on C sequestration was the net sink of atmospheric CO2 with C accumulation mainly in the growing trees and the forest floor [ 7- 11].
The results show that soil mulching has beneficial effect on SOC sequestration and strongly influence the temporal pattern of CO2 emission from soils.
By contrast, deletion of either gene had no effect on sequestration in the lung (Fig. 3B).
They showed that stroke volume-guided administration of fluids was successful in increasing the global end-diastolic volume index but had little effect on RBC sequestration.
Both chimeras, i.e. UCP2UCP1 and UCP3UCP1, had no effect on mitochondrial sequestration of intracellularly released Ca2+ while these UCP mutants mimicked the effects of the wild-type isomers regarding a strong enhancement of mitochondrial uptake of entering Ca2+ (Fig. 1C).
Those models that do include prevalence-dependent behavior almost exclusively assume behavioral changes that are depressive in their effect on the epidemic, protective self-isolation (sequestration) being the most common.
Fluid loading has little effect on sequestration and increases the risk of complications, particularly pulmonary edema, a condition that can develop suddenly and unpredictably and that is frequently fatal in this population.
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