Sentence examples for effect on the potency from inspiring English sources

Changes of the parent structure at these positions have a crucial effect on the potency and efficacy of the ligands.

Removing the moiety (generating compound E67-2) has no effect on the potency against KIAA1718 but, unexpectedly, lost inhibition against G9a-like protein by a factor of 1500.

However, compound 6 was approximately a 1000-fold poorer inhibitor than compound 2. Most significantly, inhibition studies with compound 7 and a peptide bearing sulfonomethylphenylalanine revealed that the fluorines have little effect on the potency of the DFMS-bearing inhibitors.

Structure activity relationship study shows the critical importance of the C2 modifications on the activity against MDR cancer cell line, while the C10 modifications have a rather minor effect on the potency with some exceptions.

Disruption of NFAT binding through the deletion of the FKH domain (Foxp3ΔFKH) had only a minor effect on the potency of the repression of c-Rel mediated NF-κB activation (Fig. 5B).

However, the selective β1-adrenoceptor antagonist CGP-20712A had no effect on the potency and maximal efficacy of olodaterol.

Various types of karma are classified according to their effects on the potency of the soul.

Therefore, introduction of the PEG linker at the N-terminus of the PT has only minimal effects on the potency of the peptide toward both WT and E275C gproteinsteins.

It was found that an aromatic ring must be present in the position occupied by the 2,4-dichloro-5-methylphenyl group in the lead compound, but changing the functional groups generally has little effect on the antileishmanial potency.

Modification of the substituents on the phenyl 'group D' (solubilizing group) of the imidazole inhibitors is expected to have a minimal effect on the BRAF potency but could modulate the cellular activity or the physicochemical properties of this series.

Furthermore, the comparatively high incidence of this tumour in childhood increases the probability of midazolam being co-applied to TMZ, therefore possibly increasing clinical relevance of the supposed effect on the cytotoxic potency of TMZ.