Sentence examples for effect on the internalization from inspiring English sources
As expected, Cdc-42 N17 had only a slight effect on the internalization of Tfr (Table 1, and Figure S4) thus indicating that in FRT cells PrPC might be internalized via a raft-mediated pathway dependent upon activation of Cdc-42.
The half-life of HER2 protein was 8 h, and trastuzumab has no significant effect on the internalization of HER2.
However, a significant reversible effect on the internalization of the parasites by macrophages was achieved), but this effect was less evident for the adhesion index.
However, down-regulation of this enzyme had no effect on the internalization or targeting of RNP (Fig. 2D; supplementary material Fig. S1).
Consistent with Hrb functioning as a SNARE-specific adaptor, depleting HeLaM cells of Hrb by siRNA had no effect on the internalization and intracellular accumulation of EGF nor on its degradation when compared to mock transfected cells.
The internalization of GFP-Smf1 was normal in csr2Δ bsd2Δ cells, but when we combined mutations of both arrestins, there was a stronger effect on the internalization of Smf1, suggesting that Ecm21 and Csr2 have redundant functions (Fig 2A).
Moreover, wt, CA or DN mutant forms of Cdc42, which is required for targeting GPI-anchored proteins further to early endosomes, showed no inhibiting effect on the cytoplasmic internalization of baculovirus in 293 cells (Figure S3C, S3D, S3E).
With respect to the MBCD effect on TTR internalization the data show no significant changes on internalized V122I TTR at 4°C (5.9±1.7 versus 6.4±4.2% without versus with MBCD, respectively) and a slight decrease at 37°C (16.1±0.2 versus 10.8±3.3% without versus with MBCD).
