The CME deceleration has only a small effect on the fitted direction, resulting in fitted values about 1 4° higher than the actual values.
We did not detect any contribution of HS-induced non-receptor currents, since subtracting the small current remaining after blocking NMDA and AMPA currents by 50 μM AP5 (Ascent) and 10 μM DNQX (Tocris, Bristol, UK) had a negligible effect on the fitted model rates.
The observed high correlation among covariates has effects on the fitted logistic regression models.
Such constraints are necessary, inter alia, to limit the distorting effect of aftershocks on the fitted parameters.
The run rate was not affected by exposure, but there was a significant main effect of sex on the fitted mean [ F 1,21)=6.19; p=0.02], with males responding at a faster rate than females.
There was a main effect of exposure on the fitted mean number of first-choice errors [ F 2,17)=58.55; p <0.0001], as well as a significant exposure-by-sex interaction [ F 2,17)=10.18; p=0.0012].
Interaction terms were tested between all biologically plausible sets of terms by including interactions in the model one at a time to assess their effect on the fit of the model.
From Figure 4, the addition of the fifth parameter, which is a measure of location, has some effect on the fit.
For each step in the search, part of the model is randomly perturbed, the effect on the fits to the observations is assessed, and if the fits improve, we keep the new model, otherwise we try another perturbation.
In contrast, sampling frequency had only a minor effect on the fit parameters in the case of the 300-s infusion simulations, despite some significant differences between the fits with different sampling intervals.
For the purpose of linear regression, this corresponds to decomposing the parameter vector into a reduced number of components that can be determined with certainty based on the data, while the remaining components are poorly determined, i.e. they are 'nonidentifiable', and are discarded with negligible effect on the fit.
