Sentence examples for effect on the disposition from inspiring English sources

This study was designed to investigate the induction of CYP2E1 in obese Zucker rats and its effect on the disposition kinetics of chlorzoxazone (CZX).

Coadministration of Lepidium sativum showed moderate effect on the disposition profile of CsA in rabbits.

The results elaborated the CAPE-mediated inhibition of NF- κB-dependent transcription showing no effect on the disposition of IB κB (cytoplasmic NF- κB inhibitory protein).

The covariate effect on the disposition parameters (unbound clearance CLunbound, central volume of distribution Vc, and dissociation constant KDAAG) were then examined using the final base model.

The pharmacokinetic properties of i.v. ARS overall were similar in pregnancy and in the same women post partum in a healthy state and neither pregnancy nor disease had a major effect on the disposition of ARS or DHA.

The interaction evaluation shows that chloroquine has significant effects on primaquine pharmacokinetics, whereas primaquine has negligible effects on the disposition of chloroquine.

On the basis of the results of the pharmacometric analysis [ 14], verapamil, quinidine, and dronedarone were determined to have the potential for clinically meaningful effects on the disposition of edoxaban.

This task is complicated by two factors: (i) the low association constants represent a challenge for the prediction methods; and (ii) the low-affinity binding to the abundant protein results in an easy replacement of the bound chemical by another, only slightly better ligand, with subsequent significant effects on the disposition of both compounds.

Because the in vitro co-localization experiments described earlier suggested that neuroglian could be found both in and outside of WGA-defined membrane domains, we labeled the brains of MβCD-treated and vehicle-injected control animals to determine the effect of MβCD on the disposition of neuroglian.

The chapter takes a look at the subject of insulation and insulation levels and examines the effects of these on the disposition of the windings.

This is the first meta-analysis to clarify the effects of smoking on the disposition of these drugs.