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In this model, different cytokines and infiltrating inflammatory cells have a catabolic effect on the articular cartilage.
Animal data suggested a protective effect on the articular cartilage with the addition of corticosteroids to antibiotic therapy.
The increased tolerable physical load might entail a chondroprotective effect, since it has been proved that moderate mechanical loading has an anticatabolic effect on the articular cartilage either through the action of CITED2 or by suppressing NF-k β activation [ 52].
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Specifically, effects on the articular cartilage and the development of OA, the lateral meniscus and the subchondral bone were investigated (Madry et al. 2013b; Madry et al. 2014b; Ziegler et al. 2013; Ziegler et al. 2014).
However, the effects on the articular cartilage were more modest.
Positive effects on the articular chondrocytes, including the upregulation of Col-II and aggrecan or downregulation of Col-I expression, were observed following incubation with 17 β-estradiol in female chondrocytes.
Our study, for the first time, investigated the effect of running intensity, expressed as percentage of VO2max, and an intensity-dependent effect was suggested on the articular cartilage.
An intensity-dependent effect was suggested on the articular cartilage.
The histological effects in the colon seemed to be more complete than those seen in the tarsal joints because only a modest effect was seen on the articular cartilage lesions, as reflected in the Mankin score.
Elevated levels of fat and n-6 polyunsaturated fatty acids have been found in OA bone [ 2], whereas n-3 polyunsaturated fatty acids have been shown to alleviate progression of OA through an effect on the metabolism of articular cartilage [ 3].
As a whole, this study has utilized the microcell culture system to mainly explore the stimulating frequency effect of compressive loading on the articular chondrocytes functions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com