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To explore the antiepileptic potential of baclofen further, we tested its effect on stimulus train-induced bursting, an in vitro model of hippocampal epileptiform activity.
5-HT depletions in the amygdala and the OFC reduced the impact of reinforcement on behavior (regardless of affective valence) with much less of an effect on stimulus or side stickiness.
The analyses of stimulus control, however, did not reach the conventional level of significance (p = 0.09) suggesting that PCB exposure had little effect on stimulus control or that age differences in the added controls have affected the results.
Whilst concurrent stimulus presentations within the one modality (e.g., auditory-auditory or visual-visual) can have an interfering effect on stimulus perception, there is no such performance decrement when two concurrent stimuli are presented across different modalities (i.e., auditory-visual), even when stimuli are semantically incongruent.
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This could explain the abolition of the fast positive response seen in our 7-NI-treated mice in Experiment 2 without necessarily involving a drug effect on stimulus-induced changes in CBF.
A number of previous studies in extrastriate visual cortex reported that attention increases the ongoing activity in addition to its effect on stimulus-driven activity (Luck et al. 1997; Williford and Maunsell 2006).
Benefits from multisensory processing can affect a range of different measures from reaction times, detection rates or accuracy of stimulus identification as well as learning effects on stimulus processing [11].
No long-term exposure effects on stimulus control were observed in WKY/NHsd.
These masking effects (on stimulus detection) may interact with crowding effects (on identification) at the closest target-flanker separations.
A repeated-measures ANOVA yielded a main effect of stimulus on intensity ratings [F 7, 77) = 19.97, p<.0001].
Evaluating these data by mixed-effects modeling, we found a significant main effect of stimulus on response times, F 3, 15) = 15.24; p <.001.
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