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Loss of GnRH neuron number, consequent to loss of necdin, coupled with loss of proper feedback circuitry from loss of MAGEL2, would be predicted to have a more serious effect on reproductive function in individuals with PWS with congenital absence of both genes.
Irradiation may have a profound effect on reproductive function.
Previous studies where direct-fed microbials [ 46, 49] were used, also had no effect on reproductive function.
In this selected review, we evaluate the evidence that certain environmental compounds exert their effect on reproductive function via a direct action on the pituitary gland.
The high survival rate and young age of patients with TC entails that the treatment effect on reproductive function, fertility and offspring health is a very significant factor.
Germ-cell specific ablation of Cyp51a1, the enzyme that converts lanosterol to ff-MAS, markedly reduced testicular t-MAS concentration but had no effect on reproductive function in male mice (Keber et al., 2013).
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Additionally, heavy drinking over time has been found to have a negative effect on reproductive functioning in women.
Studies have shown that BPS, a common replacement for BPA, could have similar negative effects on reproductive function and fetal brain development.
Experimental studies, however, show that acupuncture has substantial effects on reproductive function.
HT requires lifelong thyroid surveillance, particularly in women of childbearing age to avoid adverse effects on reproductive function.
However the mechanisms involved in the reported adverse effects on reproductive function remain unestablished.
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