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Taken together, these data infer that Tanshinone IIA therapy conveys a direct protective effect on renal tubules.
However, toxicological information of their effect on renal cells and the mechanisms involved remain sparse.
There was no significant effect on renal function in either group.The results of this study suggest that adding EDTA to propofol does not adversely affect cation homeostasis or renal function when used for sedation of ICU patients with renal insufficiency.
More recently, with Ang II type 1 receptor (AT1) receptor antagonists a similarly protective effect on renal function was seen in patients with type 2 diabetes.
Pentamethylquercetin (PMQ) has been shown to possess glucose-lowering properties, but its effect on renal fibrosis in diabetes is still unclear.
Cyclosporine increased renal medullary oxygenation 2 h after ingestion of a single dose, whereas indomethacin and tacrolimus showed no effect on renal oxygenation.
It is assumed therefore that the COX-2-selective inhibitors, rofecoxib and celecoxib, would have an effect on renal function similar to that of nonselective NSAIDs.
Furthermore, THC has protective effect on renal damage resulted from chemotherapy such as cisplatin for the treatment of cancer [12].
Maternal methadone caused a significant deficit in renal NE which was most pronounced at two weeks of postnatal age; direct methadone had less effect on renal NE.
In contrast, intravenously administered inorganic nitrite was shown to exert no effect on renal IRI whereas topically applied inorganic nitrite improved renal function in renal IRI [51, 52].
Conversely, therefore it behooves us as clinicians to be cognizant of the elevated IAP and its effect on renal function is often the first sign of impending ACS.
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