Sentence examples for effect on potency from inspiring English sources

The halogens (7b d) and para-fluorobenzyl substituents (8a d) on carbazol-1-one ring had little effect on potency.

There have been clinical trials – it has no effect on potency.

After adjusting for age, baseline potency, and treatment type, use of a phosphodiesterase type 5 inhibitor appeared to have no effect on potency at three years.

Mutation of Y6.48 to alanine significantly reduces agonist potency (see Table 1) for both receptors, but mutation of Y6.48 to phenylalanine had almost no effect on potency.

158b, 167a Interestingly, the absolute stereochemistry of the covalent inhibitors had little effect on potency in either the AD-169 or Davies strain.

An SAR study focused around the phenyl group of compound 5 c identified substituents that had only a moderate effect on potency and those that did not bind (KD>200 μ m).

Other residues of OxB had a negligible effect on potencies with respect to both receptors.

Other residues of OxA had a negligible effect on potencies with respect to both receptors.

The effects on potency of cruzain inhibition of replacing a nitrile group with alternative warheads were explored.

Conversely, the replacement of all other residues with Ala led to much smaller effects on potency and these positions were considered to be noncritical.

The 4-position of the central pyridine has been identified as a site that tolerates various substitutions without deleterious effects on potency and selectivity.