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In contrast, motor-neuron-specific over-expression of MnSOD had no detectable effect on life span.
It has only a modest effect on life span, but it causes costly chronic illnesses, like diabetes.
But there is no proof that calorie restriction works in people, largely because it is difficult and expensive to study; it can also take decades to measure an effect on life span.
Sinclair's team is testing the compounds' effect on life span, "but we may know if they can treat a disease in humans before we know if mice live longer," he says.
Given the likelihood that any sirtuin drug will not be perfect, Guarente envisions a modest effect on life span, but a major effect in health span (the period during which we are healthy and active).
It looked at various markers of disease but did not try to assess resveratrol's effect on longevity, given that rhesus monkeys live 40 years and it takes a long time assess any effect on life span.
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For the most part, genes have little effect on life spans.
And might the policies that Congress is contemplating to ameliorate poverty — like raising the minimum wage — have a further effect on life spans, too?
Moderate level over-expression of MnSOD has beneficial effects on life span.
Notably, royal jelly-based diet is not only atypical, but also toxic for Drosophila and even at concentrations much lower than those used for bee larvae has strong detrimental effects on life span, productivity and can negatively affect developmental processes57,59.
The jury is still out on the diet's effects on life span and age-related diseases in rhesus monkeys, which live longer and are more closely related to humans than any other animals in which the diet has been studied.
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