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With decreasing β 2 to 0.001, the focusing stabilizers had a better effect on imaging the sharp interface than those results with smooth model constraints (Fig. 4a, b).
There is also the risk of a circular logic: imaging biomarkers may provide key evidence of disease modification, but until we have a treatment that is truly disease modifying it is unclear what its effect on imaging biomarkers will be.
Analysis code depends on software, operating systems, and libraries that are regularly updated (see, e.g. [ 34] for an effect on imaging results).
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These results require confirmation but may suggest that treatment earlier in the disease may be more likely to show effects on imaging endpoints.
When analyzing longitudinal MRI data, it is important to control for effects on imaging parameters that are a consequence of repeated measurements/time, rather than effects of the treatment.
A similar sample size of several hundred is often needed for the most basic analyses of genetic effects on imaging measures, such as testing the relationship between variation at a single genetic locus and the BOLD signal during working memory [ 13, 14], or to identify the combined effects of selected multiple genes on brain structural variation [ 15].
We aimed to determine its sensitivity/specificity, document tumour-to-stromal contrast and establish the effect of imaging on surgical management.
The effect of imaging method on pressure drop was 24 percentage points due to the differences in airflow distribution and airway geometry.
The effect of imaging time on the distribution volume ratio DVR r obtained with the convolution approach at each time point t was compared with the value obtained with the total imaging time (midscan time point 87.5 min, total imaging time 90 min) as a reference.
The birds were placed on a reverse day night cycle 1 week before the first imaging session to minimize effects of imaging on their daytime behavior and were imaged longitudinally starting 1 2 nights prior to deafening.
Our approach allowed a comparison of imaging strategies but no direct evaluation of the effects of imaging on patients' management and outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com