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In addition, other papers have estimated the effect on cost effectiveness of particular features of one or both vaccines, such as warts protection, 69 impact on non-cervical cancers, 70 cross protection, and duration of protection.
Broadened prevention of AOM would have an important effect on cost effectiveness of vaccination [ 75- 77].
Ultimately, this has an effect on cost effectiveness of screening (Pignone, 2005), and it will be important to monitor closely trends in positive rates over time as the programme rolls out; we have demonstrated that rates can vary considerably.
Deaths from non-breast cancer causes in women diagnosed with breast cancer had a small effect on cost effectiveness, and the cost of treating overdiagnosed or metastatic breast cancer had a limited effect.
A significant effect on cost effectiveness and cost utility results was observed as a result of changing the value of the discount rate of costs and effects due to the long time horizon used in analysis; however, these effects did not change the overall conclusions of the primary analysis.
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This analysis is one part of the complete evaluation, and the Whole System Demonstrator trial in its entirety will allow a wider discussion of issues around the effects on cost effectiveness, quality of life, and patients' and carers' experiences as well as changes at the organisational level.
Although TB treatment outcomes affected projected survival substantially, they did not have an important effect on cost-effectiveness results.
Both parallel processing and refrigeration would be expected to impact the estimated sensitivity of TB culture; Figure 2 shows the expected effect on cost-effectiveness of a 25% variation in this parameter.
However, adherence in daily practice will be lower and therefore have an effect on cost-effectiveness.
The mechanisms underlying these findings and their effect on cost-effectiveness of joint replacements, merit further research.
The utility value of taking a pill daily can have an important effect on cost-effectiveness analyses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com