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Knockdown of GAP19 showed no statistically significant effect on cell morphology while knockdown of RECK reduced cell rounding suggesting that in the morphological switch driven by miR-200c, the reduction of MARCKS levels by miR-200c is dominant over the effects of RECK reduction.
Fiber orientation had a pronounced effect on cell morphology and orientation.
As shown in Figure2A, BC membranes supported cell adhesion and had no adverse effect on cell morphology.
The SC molecules alone had no effect on cell morphology or growth; apparently, the conjugates of CNT/SC are not toxic to the cells.
Seeing the effect of Hcl1 on in vitro growth, we then checked its effect on cell morphology.
A previous study showed that high-levels of Bud3p exhibited deleterious effect on cell morphology and septin organization [16].
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The few effects on cell morphology indicate promise for the synthesized system for manipulating axon regeneration.
Thus, it appears that the constructed nanosphere system has no detrimental effects on cell morphology and cytoskeleton, and may enhance the formation of actin filaments.
Effects on cell morphology were mostly dependent on surface topography, while cell proliferation and cell differentiation were largely dependent on the biomolecular signaling from the ELR membranes.
To test their biocompatibility, assays of cell adhesion, survival, migration, effects on cell morphology, axonal growth and axonal guidance were performed.
Epifluorescence microscopy analysis of CNT/DNA conjugates revealed distribution in the cytoplasm of cells and did not show adverse effects on cell morphology, proliferation, or viability during a 72-h incubation.
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