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Polyethylene-co-vinyl acetate (EVA) concentration showed a significant effect on all responses.
X1 showed a negative quadratic effect on all responses evaluated (P < 0.05).
Results showed that ethanol content in CO2 has a more significant effect on all responses than pressure and temperature.
The results showed that irradiation power and moisture content had a high significant effect on all responses while irradiation time has a significant effect only on extraction yield.
As shown in Table 2, the emulsifier concentration had the most significant (p < 0.05) effect on all responses compared with other emulsion components.
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Of the four parameters involved, applied current had a considerable effect on all the response factors.
Results indicated that distilling temperature and distilling pressure were two important factors in MD process, both of them and their interaction term had significant effects on all the responses (P < 0.05), and the effect of distilling pressure was more significant than distilling temperature.
Protease showed high activity in the PEG-rich phase, also MPEG and CCIT were shown to exert positive effects on all responses.
The statistical analysis of the results revealed that PEG400 had positive effects on Q%2h, Q%6h and Q%12h, hole diameter had positive effects on all responses and coating level had positive effect on Q%6h, Q%12h and negative effect on RSQzero.
Statistical analysis of results showed that the linear terms of all the process variables have a significant effect on all the responses.
The extraction temperature had the most significant effect on all the responses (p < 0.0001).
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