Regardless the specific adherence support, elements of module 1 and 2, such as an individual medication plan and patient counselling regarding prophylaxis, detection and treatment of adverse effects, might have had a beneficial effect on adherence of initially adherent as well as initially non-adherent patients as shown previously.
In two studies [ 38, 39], the intervention was delivered on one occasion, with a statistically significant effect on adherence outcomes, but the short follow-up period did not allow for an estimation of the intervention's waning effect over time.
First, the effect on adherence was immediate in the first 2 months and occurred mainly among poorly adherent patients.
We expected health locus of control to have a marked effect on adherence to a treatment regimen, such that internally oriented patients would adhere more than externally oriented patients.
Finally, we expected self-efficacy to have a considerable effect on adherence to a treatment regimen, such that patients with high self-efficacy would adhere more than patients with low self-efficacy.
Prior studies have begun to explore parental beliefs regarding controller asthma medications and their effect on adherence.
Physician noninvolved studies were more likely (35.0% of studies) to show a medium or large effect on adherence compared to physician-involved studies (31.3%).
Factors that can have a positive effect on adherence are positive family functioning, close friends, internal locus of control, treatment with immediate benefits, and a good collaboration between doctor and patient [34].
The lack of adherence to treatment not only prevents the achievement of control targets but may additionally represent a financial burden to the health system and pose a major obstacle to effective treatment [44] In this sense, LC oral powder has already demonstrated its efficacy, and its positive effect on adherence to treatment in CKD patients [45].
The effect on adherence of adding another medication needs to be considered, as does the extra cost, though that is offset by the reduced insulin dose required.
Test messaging has a significant effect on adherence to ART.
