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Only one animal study evaluated the effect of various statins after the onset of sepsis [48].
Only one animal study evaluated the effect of various statins after the onset of sepsis [ 48].
Early pilot and single-center retrospective studies found a positive effect of various statins on the incidence of acute rejection and patient survival in kidney transplantation[ 18, 24].
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To investigate the effects of various statins on yeast cell sterol levels, the H strain was treated with the four statins or buffer, sterols were isolated and submitted to GC/MS analysis.
Another limitation was the inability to evaluate the effect of various types of statins, given the considerable variation in their bioavailability 46.
Study duration appeared to have no effect on lipid-altering capacity of the various statins (additional file 5).
It has been shown that comorbidities (e.g., diabetes mellitus, hyperlipidemia) and comedications (e.g., angiotensin-converting enzyme inhibitors, statins) deteriorate cardioprotective effects of various conditioning stimuli (e.g., ischemic preconditioning and postconditioning) [ 2, 6, 7], however, only a few papers examined these chronic confounding factors in RIC so far.
There are also concerns regarding increased risk of adverse events (Cournot et al 2006) and drug interactions, as well as the effect of statins on the various comorbidities in this age group.
We observed similar effects of other statins on HMGR mRNA levels in cultures of HepG2 cells treated with various statins (results not shown).
Effects of statins on various haemostatic parameters provide further evidence for beneficial effects on endothelial function.
This suggests a beneficial effect of hydrophilic statins over lipophylic statins on adipose tissue dysfunction.
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