Sentence examples for effect of this variant from inspiring English sources
The functional effect of this variant is an increased MAO A activity which, leading to hypermetabolism of amine neurotransmitters, might cause a lower level of serotonin, a condition often described in association with migraine pathophysiology [13].
This effect is likely based on the presence of the G allele, which showed a significant p-value of 0.009 for the odds ratio test in the total population (OR = 0.48, 95% CI = 0.28-0.84) and 0.007 in the MRM sub-population (OR = 0.45, 95% CI = 0.25-0.81), which suggests an important protective effect of this variant on the MRM phenotype.
It is notable, however, that the effect of this variant on susceptibility to gout is only present in our male subcohort.
Third, the strong heterogeneity observed in the relationship between the Gly460Trp polymorphism and hypertension precluded a consistent estimate of the effect of this variant, even when analyzed by ethnicity.
The biochemical effect of this variant was assessed in vitro and the physiological effect was investigated among Danish and Czech individuals with a familial predisposition for obesity and in a population-based study sample.
The "5.A" haplotypic variant, representing a combination of allele 5 of D17S798 and the "A" allele of SNP rs28936, had 43.8 expected pseudo-cases vs 22.5 expected pseudo-controls, which suggested a deleterious effect of this variant.
Nevertheless, more experimental evidence is required to understand the effects of this variant on KLK15 expression and/or splicing.
The A946T SNP does not reside in either the helicase or CARD domains, and therefore the biological effects of this variant are unknown – although the variant does lie in a region that is highly conserved between mammals, suggesting functional importance.
Furthermore, GKRP-WT and GKRP-P446L displayed comparable Δ G(H2O) of denaturation (1.56 and 1.55 kcal/mol respectively) and unfolding/refolding patterns, suggesting that structural instability is unlikely to explain the metabolic effects of this variant protein.
