Sentence examples for effect of these variants from inspiring English sources
Given the availability of smoking measures in our sample, we also tested if an effect of these variants on smoking quantity (CPD) or nicotine dependence (FTND) was detectable in our sample.
Hence, investigating the effect of these variants in combination with other genetic variants or environmental factors would help elucidating their potential role in NAFLD.
In addition, because esophagitis typically presents 4 6 weeks following initiation of radiation therapy, we also analyzed the effect of these variants using logistic regression.
However, overall there is ambiguity regarding the effect of these variants and in our previous study none of them were associated with either trait [3].
Subsequent studies of the effect of these variants on estimates of the beta-cell function and insulin sensitivity have been inconclusive.
It may be possible to investigate the aggregate effect of these variants, for example Purcell et al. [22] showed a large number of SNPs (with p values up to 0.5) from a schizophrenia GWAS demonstrate predictive power collectively.
The next great challenge of pharmacogenetics is to pin down the cellular location and effect of these variant proteins on the pathways and networks that govern individual variation in responses to drugs and other exogenous chemicals.
This review will focus on the most common and widely studied SNPs of oxidative DNA damage repair proteins trying to bridge the information available on biochemical and structural features of the repair proteins with the functional effects of these variants and their potential impact on the pathogenesis of disease.
"The effects of these variants didn't just add together in a simple way," says Burn. "There were some situations where a variant was a disadvantage unless it was in the presence of another variant when it became an advantage.
We aimed to replicate this finding in an independent cohort from the Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C and to investigate the effects of these variants beyond week 4. METHODS:Genetic material was available from 318 patients.
These consistent findings from three independent cohorts strongly support the risk effects of these variants on GSIS to predispose hyperglycemia in Chinese.
