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It may take much longer to see any effect of these supplements".
Another limitation of this study is that no information on dietary supplements was available, and we were therefore unable to adjust the effect of these supplements in the statistical analyses.
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Despite the common use of herbal supplements in the United States and elsewhere [2], the precise mechanisms associated with purported beneficial effects of these supplements are unknown.
The effects of these supplements on human atherosclerosis progression were evaluated in a few small studies, which were inconclusive (17– 217.
We evaluated the combined effects of these supplements on arterial stiffness, endothelial function, markers of inflammation, oxidative stress, glucose and lipid metabolism, and blood pressure.
Considering the large number of Hoodia-containing products in the market, the presented data should be regarded alarming, due to possible cardiovascular side effects of these supplements.
Furthermore, previously published series also suggest that many of these patients are unaware of any possible side effects of these supplements and do not tell their treating physician they are taking them (38).
Despite these concerns, one may be impressed by the large number of papers (more than a hundred; only a few cited here) that almost without exception reported beneficial effects of these supplements in osteoarthritis patients, horses and small animals.
Recently, the use of different antioxidant agents such as vitamin E on improving endothelial cells functioning has been suggested which may be due to the effects of these supplements on reducing superoxide-dependent oxidative stress.
However, the effects of these supplements on metabolomics results may always be present in human studies, and the possible misinterpretation of the acquired data is not to be underestimated.
More research is now needed not only on the combined effects of these supplements in long-term maintenance of H. pylori infection but also in determining the mechanistic link between diet and infection, as well as diet and progression of H. pylori -associated disease.
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