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Grain protein content was used as a covariable to evaluate the effect of these loci independently of the variation in protein content among lines.
Recently, studies in other populations than those of European descent have both yielded new loci and information on their effect across ethnicities [15] [17], representing an early attempt to assess the effect of these loci globally.
Such ancestry-shift refinement mapping of each of the loci would enable clarification of the observed signals and determination of ancestry-specificity or the potential global effect of these loci on BMD.
The effect of these loci was also time-dependent.
However, the effect of these loci on prospective mortality is not yet known.
These reciprocal congenic strains are valuable resources for studying the effect of these loci on susceptibility to CRGN.
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Magnitudes of effect for these loci were moderate and ranged from 33 to 64%. S. pennellii alleles for the other ten QTL were responsible for decreases in flavonoid content of at least 33%.
We analyzed the effects of these loci on glucose levels in the controls.
However, there are still loci that failed to be replicated in our samples even though we had enough statistical power, e.g. GIPR, which suggests heterogeneous effects of these loci may exist in the Chinese comparing with European descent populations.
Second, we only analyzed the effects of these loci on insulin sensitivity and secretion in the normal glucose regulation subjects as most of the type 2 diabetes patients were receiving glucose lowering therapy.
Smaller phenotypic effects of these loci could not be ruled out with our sample size.
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