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Although these results are very promising, it is currently unpredictable whether the effect of these identified sensitisers is selective to tumour cells or if they would also sensitise non-transformed cells to TRAIL and thus cause toxicity.
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Until recently, prevention of CIP/CIM was solely based on minimising the effects of these identified risk factors.
Assessments of the effect of the identified sequence variants have been limited in populations of other ethnicities.
We next investigated the effect of the identified Y431X truncating mutation on PINK1 kinase activity.
Afterwards, effects of the identified parameters on the dependent variable(s) can be validated within experimental studies (maximising internal validity).
dPercentage of phenotypic variation explained by additive effects of the identified QTL.
In addition, we examined the biological effect of these compounds and identified one that had off target effects which reduced MAPK activity.
The fit multiple QTL model in R/qtl was used to statistically validate the independent effect of each identified QTL.
Moreover, no adverse effect of treatment was identified when these results were analyzed on an individual-subject basis.
As a molecular key for the protective effect of FX06 we identified the src kinase Fyn.
However, the effect of identified qDTYs in diverse genetic backgrounds remains unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com