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In addition to the structural illustration of main fractions, the antiviral effect of these fractions was assessed against HSV-1 and HSV-2 and DENV-2, which surprisingly exhibited potent inhibitory effects with low cytotoxicity together.
It's worth mentioning, that the higher potency of the crude extract against cancer cell lines in special HeLa and MCF-7 relative to all fractions (compounds) from the same extract, might be attributed to auto-synergistic effect of these fractions within the same extract.
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This may complicate the interpretations of the biological effects of these fractions.
The effect of the fractions of the extract on PCV on days 0 and 4 is indicated in Figure 1.
For each of these analyses, all marker densities were used to quantify the effect of the fraction of genome covered.
Alternatively, the effect of the fraction studying FP-I, is larger but also non-significant in the two specifications considered.
The antibiotic effect of the fraction on the MRSA strains was evaluated on Mueller Hinton agar plates (Difco, USA).
The active fraction, which improves the survival rate and prevents ischemic reperfusion damage, was used to test the therapeutic effect of this fraction on myocardial infarction.
Ideally, the exposure and effects of these different fractions should be differentiated, but this is in practice difficult due to the dynamic changes occurring during the incubation period.
In contrast, very limited information is available concerning any direct immunomodulatory effects of these oligosaccharide fractions and the underlying mechanisms.
The desulfurization effect of different fractions in crude oil was also investigated.
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