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Further studies are, however, needed to clarify the effect of these combinations in antitumor chemotherapy.
Additionally, the cytotoxic effect of these combinations on BCR ABL-negative cells was investigated.
The effect of these combinations on clinical and inflammatory parameters and fertility traits on a commercial dairy herd were investigated.
Preliminary conclusions presented in late 2008 at the European Association for the Study of Diabetes in Rome (Italy) suggest a favorable effect of these combinations on glycemic control with a moderate increase in body weight after 52 weeks.
We were interested in studying the effect of these combinations on the tumor epithelial cells and stromal cells as a growing body of literature highlights the cross-talk between malignant hepatocytes and the surrounding peri-tumoral stroma as a key modulator of hepatocarcinogenesis and chemoresistance [ 1].
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In addition, we analysed tumour tissue to determine the mechanistic effects of these combinations.
The effects of these combinations were significantly greater than those seen with any of the cytokines alone.
To evaluate the interactive effects of these combinations, the phenotypic values of the RIL were separated on the basis of each genotype in the QTL regions (Fig. 6).
The effects of these combinations of a c-Met inhibitor with SN38 were synergistic (CI<0.9) in OCUM-2M/SP, OCUM-2D/SP, and OCUM-2MD3/SP.
APOE polymorphisms and haplotypes have been associated with AD and other human pathological conditions, but the effects of these combinations on healthy populations are not completely known.
For example, Raymond et al. [ 10] reported that synergistic antiproliferative effects were observed when oxaliplatin was added to 5FU, and the synergistic effects of these combinations were maintained in the 5FU-resistant colon cancer cell line, HT29-5-FU.
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