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Another limitation of the study is that controls did not have any coronary angiogram performed on them, and some of them may have clinically asymptomatic CAD, which may have led to under-estimation of the effect of the variants tested here.
We also annotated the SAIF genome against SNPedia to understand the effect of the variants.
Finally, we tested the effect of the variants on SH2B1 enhancement of NGF-induced neurite outgrowth.
To obtain further functional insights, we studied the effect of the variants on a FOXO3a-based reporter system.
Functional studies in relevant tissues are needed to understand the effect of the variants on downstream biological pathways.
To check the effect of the variants in the AIRE gene expression, two different approaches were used.
Similar(39)
In addition, the test for trend did not suggest a linear effect of the variant alleles across the genotypes on triptan non-response for either polymorphism.
We also investigated for a potential linear effect of the variant alleles across the genotypes on triptan non-response using a test for trend.
The effect of the variant on AE3 function has not been assessed.
This is highly indicative of how low the effect of the variant is on the genetics of ET in the French-Canadian population.
The main effect of the variant genotypes on the risk of lung cancer was estimated by odds ratios and their 95% confidence intervals using unconditional logistic regression analysis.
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